发明名称 |
Ocular implant made by a double extrusion process |
摘要 |
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release. |
申请公布号 |
US8778381(B2) |
申请公布日期 |
2014.07.15 |
申请号 |
US201313797230 |
申请日期 |
2013.03.12 |
申请人 |
Allergan, Inc. |
发明人 |
Shiah Jane-Guo;Bhagat Rahul;Blanda Wendy M.;Nivaggioli Thierry;Peng Lin;Chou David;Weber David A. |
分类号 |
A61F2/16;A61F2/02;B29C47/04 |
主分类号 |
A61F2/16 |
代理机构 |
|
代理人 |
Wine Laura L.;German Joel B.;Condino Debra D. |
主权项 |
1. A method for making a bioerodible implant for treating a medical condition of the eye, the method comprising:
a) milling a hydrophilic ended poly(D,L-lactide-co-glycolide) (PLGA) copolymer; b) milling a hydrophobic ended poly(D,L-lactide-co-glycolide) (PLGA) copolymer; c) blending the milled polymers together with particles of a steroidal anti-inflammatory agent to form a blended mixture comprising hydrophilic ended PLGA, hydrophobic ended PLGA, and a steroidal anti-inflammatory agent, wherein at least about 75% of the particles of the steroidal anti-inflammatory agent have a diameter of less than about 20 μm; d) carrying out a first extrusion of the blended mixture to thereby obtain a first extrusion product; e) pelletizing the first extrusion product; and f) carrying out a second extrusion of the pelletized first extrusion product, thereby obtaining a bioerodible implant for treating a medical condition of the eye; wherein the implant has a total weight ranging from about 100-5000 μg. |
地址 |
Irvine CA US |