发明名称 |
IDENTIFICATION, OPTIMIZATION AND USE OF CRYPTIC HLA-B7 EPITOPES FOR IMMUNOTHERAPY |
摘要 |
The invention provides methods for identifying a HLA-B*0702-restricted cryptic epitope in an antigen, as well as methods for increasing the immunogenicity of HLA-B*0702-restricted cryptic epitopes. The HLA-B*0702-restricted cryptic epitopes and their cognate immunogenic epitopes are useful for stimulating an immune reaction against the cryptic epitopes in a subject. Accordingly, the invention further provides pharmaceutical compositions comprising a HLA-B*0702-restricted cryptic epitope or a cognate immunogenic epitope thereof, and vaccination kits comprising such epitopes. The novel materials of the invention are particularly useful for efficiently treating patients having an HLA-B*0702 phenotype. |
申请公布号 |
PT2041160(E) |
申请公布日期 |
2014.07.11 |
申请号 |
PT20070825358T |
申请日期 |
2007.07.12 |
申请人 |
VAXON BIOTECH |
发明人 |
KOSTANTINOS (KOSTAS) KOSMATOPOULOS;STÉPHANIE GRAFF-DUBOIS;JEANNE MENEZ-JAMET |
分类号 |
C07K7/04;A61K38/04;A61P31/12;A61P35/00 |
主分类号 |
C07K7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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