Process for Producing Alpha-Fluoroaldehydes

摘要

A production process of an α-fluoroaldehyde according to the present invention includes reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a ruthenium complex. It is possible in the present invention to allow relatively easy industrial production of the α-fluoroaldehyde and to directly obtain, as stable synthetic equivalents of the α-fluoroaldehyde, not only a hydrate (as obtained by conventional techniques) but also a hemiacetal that is easy to purify and is of high value in synthetic applications. The present invention provides solutions to all problems in the conventional techniques and establishes the significantly useful process for production of the α-fluoroaldehyde.

主权项

1. A process for producing an α-fluoroaldehyde of the general formula [3], comprising: reaction of an α-fluoroester of the general formula [1] with hydrogen gas (H2) in the presence of a ruthenium complex of the general formula [2] where R1 represents a halogen atom or a haloalkyl group; and R2 represents an alkyl group or a substituted alkyl group, where R each independently represents a hydrogen atom, an alkyl group, a substituted alkyl group, an aromatic ring group or a substituted aromatic ring group; Ar each independently represents an aromatic ring group or a substituted aromatic ring group; X each independently represents a ligand with a formal charge of −1 or 0 (with the proviso that the sum of the formal charges of three X is −2); and n each independently represents an integer of 1 or 2, where R1 has the same meaning as in the general formula [1].