PYRIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELORIATION OR PREVENTION OF A VIRAL DISEASE

摘要

The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof,;;which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

主权项

1. A compound having the general formula (II), wherein X20 is NR25, N(R25)C(O), C(O)NR25, O, C(O), C(O)O, OC(O); N(R25)SO2, SO2N(R25), S, SO, or SO2; R20 is —H, a —C1-6 alkyl group or a —C(O)—C1-6 alkyl group; R21 is —H, a —C1-6 alkyl group, or a —C1-6 alkyl group which is substituted by one or more halogen atoms; R22 is —H, a —C1-6 alkyl group, or a —C1-6 alkyl group which is substituted by one or more halogen atoms; or wherein R21 and R22 can be joined together to form a 3- to 7-membered carbo- or heterocyclic ring; R23 is —R26, or —X20—R26; R24 is H, or a C1-6 alkyl group; R25 is —H, -(optionally substituted C1-6 alkyl), -(optionally substituted C3-7cycloalkyl), -(optionally substituted aryl), —C1-4 alkyl-(optionally substituted C3-7 cycloalkyl), or —C1-4 alkyl-(optionally substituted aryl); R26 is -(optionally substituted hydrocarbon group which contains from 5 to 20 carbon atoms and optionally 1 to 4 heteroatoms selected from O, N and S and which contains at least one ring); R27 is —H, —C1-6 alkyl, or —(CH2CH2O)rH; R28 is —H, or —C1-6 alkyl; R is independently selected from —C1-6 alkyl, —C(O)—C1-6 alkyl, -Hal, —CF3, —CN,
—COOR27, —OR27, —(CH2)qNR27R28, —C(O)—NR27R28, and —NR27—C(O)—C1-6 alkyl; q is 0 to 4; and r is 1 to 3; wherein the alkyl group, aryl group, hydrocarbon group and/or cycloalkyl group can be optionally substituted with one or more substituents R,or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof.