PREPARATION OF 2-METHYL-4-AMINO-5(SUBSTITUTED-1H-1,2,3-TRIAZOLYL)METHYLPYRIMIDINE DERIVATIVES AND MICROBICIDAL ACTIVITY THEREOF

摘要

Disclosed is a derivative of 2-methyl-4-amino-5-(substituted-1H-1,2,3-triazol)methylpyrimidine of general formula I and microbicidal activity thereof. In the formula, R1 represents hydrogen, I; X represents O or NH; Y represents phenyl of substituted phenyl, benzoyl or substituted benzoyl, phenyloxyacetyl or substituted phenyloxyacetyl; the substituents on the phenyl rings which Y involves are: H, halogen, nitro, cyano, CF3, C1˜4 alkyl, methoxyl, C1˜2 carboxyl or carboxylic ester groups; any position of phenyl rings can be mono- or multi-substituted by identical or different substituents. The compound has a significant inhibition effect on cucumber bacterial angular leaf spot, tomato bacterial leaf spot, cucumber brown blot, cucumber downy mildew, rice sheath blight, Gibberella saubinetii, Alternaria solani, Botrytis cinerea, Alternaria alternate and Colletotrichum orbiculare and it can be used as an effective ingredient of microbicides.

主权项

1. A 2-methyl-4-amino-5-(substituted-1H-1,2,3-triazolyl)methylpyrimidine derivative, having a structure of formula I: wherein R1 represents hydrogen or iodine, X represents O or NH, Y represents phenyl or substituted phenyl, benzoyl or substituted benzoyl, phenoxyacetyl or substituted phenoxyacetyl; and wherein each substituent on the benzene ring of Y is H, halogen, nitro, cyano, CF3, C1-4 alkyl, methoxy, C1-2 carboxy or carboxylate, the substituents are mono- or multi-substituted at any position of the benzene ring, and the substituents are the same or different.