发明名称 |
Formulations for a Tight Junction Effector |
摘要 |
Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a 5 delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine. Dissolution of Encapsulated Combination to Two Different AT1001 Beads 0 15 30 45 60 75 90 105 120 135 150 165 180 195 Time (min) |
申请公布号 |
AU2012203787(B2) |
申请公布日期 |
2014.07.10 |
申请号 |
AU20120203787 |
申请日期 |
2012.06.27 |
申请人 |
ALBA THERAPEUTICS CORPORATION |
发明人 |
PATERSON, BLAKE |
分类号 |
A61K9/14;A01N37/18;A61K9/22;A61K9/52;A61P1/04;A61P3/10 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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