发明名称 |
18F-LABELED PRECURSOR OF PET RADIOACTIVE MEDICAL SUPPLIES, AND PREPARATION METHOD THEREOF |
摘要 |
The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system. |
申请公布号 |
US2014194620(A1) |
申请公布日期 |
2014.07.10 |
申请号 |
US201214117271 |
申请日期 |
2012.05.11 |
申请人 |
Chi Dae-Yoon;Lee Byoung-Se;Park Chansoo;Lee Min-Hyung;Cha Hyojin;Cho Woojin;Kang Heewon;Kim Kyunghun |
发明人 |
Chi Dae-Yoon;Lee Byoung-Se;Park Chansoo;Lee Min-Hyung;Cha Hyojin;Cho Woojin;Kang Heewon;Kim Kyunghun |
分类号 |
C07J43/00;C07C229/36;C07D233/60;C07C43/225;C07D249/04;C07D249/06 |
主分类号 |
C07J43/00 |
代理机构 |
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代理人 |
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主权项 |
1. A precursor comprising a leaving group of a tetravalent organic salt, represented by the following Chemical Formula 1: wherein, in Chemical Formula 1, R1 is a part excluding a —X—CH2—18F part from an 18F-labeled radiotracer and represents a C1-C1000 hydrocarbon group in which a carbon in the main chain of the C1-C1000 hydrocarbon group may be non-replaced or replaced by an oxygen, a nitrogen, a sulfur, a phosphorus or combinations thereof and a hydrogen in the main chain may be non-replaced or replaced by a halogen, X represents an oxygen, a sulfur or —C(O)—, and the leaving group represents a non-substituted or a substituted C2-C50 tetravalent ammonium salt. |
地址 |
Seoul KR |