发明名称 COMPOSITIONS FOR TREATMENT OF CANCER
摘要 Compounds that are specifically toxic to cancer stem cells are disclosed.
申请公布号 US2014194463(A1) 申请公布日期 2014.07.10
申请号 US201313802018 申请日期 2013.03.13
申请人 NovaRx Corporation 发明人 KARIMI-BUSHERI Feridoun;FAKHRAI Habib
分类号 C07D257/06;C07D215/24 主分类号 C07D257/06
代理机构 代理人
主权项 1. A pharmaceutical composition comprising as an active ingredient at least one compound of formula (A): wherein: Het is pyrrolyl, pyrazoyl, imidazolyl, triazolyl, or tetrazolyl; R4 and R5 are each independently H or C1-4alkyl; each X is independently selected from the group consisting of halo, nitro, —OR6, —OCOR6, —COOR6, —R6NCOR6, —CONR62, —COR6, —NR62, —S(O)mR6, —CN, and R7; wherein R7 is C1-6alkyl, unsubstituted or substituted with halo, OR6, or NR62; each R6 is independently H or C1-4alkyl; m is 0, 1, or 2, and n is 0, 1, 2 or 3; or a tautomer thereof; or a pharmaceutically acceptable salt or solvate thereof.
地址 San Diego CA US