| 发明名称 |
METHODS AND KITS USEFUL FOR DETECTING AN ALTERATION IN A LOCUS COPY NUMBER |
| 摘要 |
A method of identifying an alteration in a locus copy number is provided. The method is effected by determining a methylation state of at least one gene in the locus, wherein a methylation state differing from a predetermined methylation state of the at least one gene is indicative of an alteration in the locus copy number. |
| 申请公布号 |
US2014193817(A1) |
申请公布日期 |
2014.07.10 |
| 申请号 |
US201414184735 |
申请日期 |
2014.02.20 |
| 申请人 |
Trisogen Biotechnology Limited Partnership |
发明人 |
HALLE David |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying locus amplification, the method comprising determining a methylation state of at least one gene in the locus, said gene being selected having an expression pattern which is compatible with two gene copies, wherein an increase in methylation state of said at least one gene in the locus compared to a methylation state of said at least one gene in a non-amplified locus is indicative of locus amplification. |
| 地址 |
Petah-Tikva IL |
