发明名称 |
MRNA Interferase from Myxococcus Xanthus |
摘要 |
A regulated deployment of a toxin gene for developmental programmed cell death in bacteria is described. M. xanthus is demonstrated to have a solitary mazF gene that lacks a cotranscribed antitoxin gene. Deletion of mazF results in elimination of the obligatory cell death during development causing dramatic reduction in spore formation. Surprisingly, MrpC functions as a MazF antitoxin and a mazF transcription activator. Transcription of mrpC and mazF is negatively regulated via MrpC phosphorylation by a Ser/Thr kinase cascade. Various methods of exploiting this novel pathway are described herein. |
申请公布号 |
US2014193878(A1) |
申请公布日期 |
2014.07.10 |
申请号 |
US201313932498 |
申请日期 |
2013.07.01 |
申请人 |
University of Medicine and Dentistry of New Jersey |
发明人 |
Inouye Masayori;Nariya Hirofumi |
分类号 |
C12N9/16 |
主分类号 |
C12N9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Somerset NJ US |