| 摘要 |
PROBLEM TO BE SOLVED: To provide stabilized antibodies directed to angiopoietin (Ang)-2 and to provide the uses of such antibodies.SOLUTION: This invention relates to an isolated antibody that binds to Ang-2. The antibody, when produced, shows production efficiency in a mammalian host cell, the production efficiency being equal to or greater than 5 times the production efficiency of the Ang-2 antibody 3.19.3. A method of preventing, treating, or managing cancer in an animal is also provided. Moreover nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are provided. A pharmaceutical composition that contains the Ang-2 antibody is administered for preventing, treating, or managing the cancer in the animal. |
