| 发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE |
| 摘要 |
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6. |
| 申请公布号 |
US2014194489(A1) |
申请公布日期 |
2014.07.10 |
| 申请号 |
US201214007835 |
申请日期 |
2012.03.28 |
| 申请人 |
Bumcrot David;Bettencourt Brian;Toudjarska Ivanka |
发明人 |
Bumcrot David;Bettencourt Brian;Toudjarska Ivanka |
| 分类号 |
C12N15/113;A61K31/713 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of TMPRSS6, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a TMPRSS6 transcript which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from one of the antisense sequences listed in Tables 2, 3 or 4. |
| 地址 |
Belmont MA US |
