Ultrasound Neuromodulation for Cognitive Enhancement

摘要

Disclosed are methods and systems for non-invasive neuromodulation using ultrasound for cognitive enhancement. Cognitive enhancement can be used for mitigation of abnormal conditions such as Alzheimer's Disease, Parkinson's Disease or stroke, or for enhancement in a normal individual. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, mechanical perturbation, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.

主权项

1. A method of deep-brain neuromodulation of a subject with ultrasound stimulation, the method comprising:
focusing one or more ultrasound transducers at one or more neural targets related to cognitive enhancement; applying pulsed power to the one or more ultrasound transducers to transmit ultrasound to the one or more neural targets; and controlling the pulsed power to enhance a cognitive function of the subject.