ENZYME DIRECTED ASSEMBLY OF PARTICLE THERANOSTICS

摘要

Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient.

主权项

1. A hydrophilic polymer probe comprising:
(i) a hydrophilic polymer probe with an enzyme cleavable moiety and at least one of (ii) or (iii), wherein (ii) is a visualizable label; and (iii) is a therapeutic agent and a targeting moiety.