| 摘要 |
<p>The present invention relates to fabrication of metallic microneedles 200 which involves two process steps: firstly providing a rough cut on a metallic block to form approximate microneedle shapes, and secondly providing a finishing cut on the rough-cut metallic block to achieve final microneedles with required surface smoothness and tip sharpness. Providing the rough cut can be achieved by using conventional manufacturing methods such as Electro- Discharge Machining (EDM) or Computerised Numerical Controlled (CNC) machining by first forming a rough cut a metallic block 500 of the microneedle array 600. The finishing cut is achieved by polishing the individual microneedles 720 on the rough-cut metallic block 500 to desired sharpness and surface finish. The microneedles 720 formed are partial or full pyramidal structures which normally have heights of 100 microns to 1,000 microns with sharp tips that can penetrate the skin painlessly and effectively. Hollow microneedles can be achieved by drilling a through hole on the solid microneedles.</p> |
