| 摘要 |
PROBLEM TO BE SOLVED: To provide a system applicable to needle-free delivery which comprises a sustained release formulation for the treatment of migraine which is debilitating neurological disease, related head pain such as cluster headache and the symptoms.SOLUTION: A system comprises: a drug delivery device; and a biphasic formulation which is comprised of a first component which provides a fast acting pain alleviation effect within one hour or less, and a second component which has high viscosity and provides a long term alleviation effect over a period of 4 hours or more. The drug delivery device is a needle-free injector, and the second component is composed of a carrier which provides controlled release of a drug over a period of 4 hours or more. The system comprises: a drug as the first component selected from the group consisting of sumatriptan, almotriptan, rizatriptan, eletriptan and zomitriptan; and a drug as the second component selected from the group consisting of naratriptan and frovatriptan. |
