USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS

摘要

C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed. Uses of these polypeptide, polynucleotides and expression vectors include the treatment of fibrosis in a subject. Thus, methods are provided for treating fibrosis, including fibrosis of the skin and/or the lung.

主权项

1. An isolated polypeptide, comprising at least 10 consecutive amino acids and at most 47 amino acids of the amino acid sequence set forth as amino acids 133-180 of SEQ ID NO: 2, wherein the polypeptide:
a) comprises amino acids 145-153 of SEQ ID NO: 2; b) has anti-fibrotic activity; and c) does not comprise amino acids 1-92 of SEQ ID NO: 2; andwherein the polypeptide is optionally amidated.