METHODS OF DETECTING OVARIAN CANCER

摘要

Methods of screening human female subject for a risk of ovarian cancer are described. High levels of calcium in serum are shown to be significantly positively associated with the risk of ovarian cancer and can advantageously be used to triage women into risk categories for more intensive testing. Also included are preoperative methods of determining if an adnexal mass is likely to be malignant or benign.

主权项

1. A preoperative method of determining a greater likelihood that an adnexal mass in a female subject is malignant or benign, comprising
providing a blood sample collected from the subject; determining a total serum calcium level and a serum albumin level in the blood sample; comparing the total serum calcium level and the serum albumin level of the blood sample to a predictive model that includes total serum calcium and serum albumin levels for a population; and determining that the adnexal mass is likely to be malignant when the total serum calcium level in the blood sample is high normocalcemic to hypercalcemic or deviates upward from normal based on the predictive model, or determining that the adnexal mass is likely to be benign when total serum calcium level in the blood sample is normocalcemic or lower, is normal based on the predictive model or deviates downward from normal based on the predictive model.