POLYMERIC IRON CHELATING AGENT

摘要

Disclosed is a water-insoluble polymeric iron chelating agent having a polymer backbone and an aromatic ring attached to the polymer backbone through an -NH-CH 2 - bond, wherein the aromatic ring has one or two first functional groups in the form of hydroxyl group and one or two second functional groups located at the ortho position with respect to the first functional group; and wherein the second functional group is -OH, -COOH, or a group represented by formula (I) wherein A represents -CH 3 , -CH 2 -CH 3 , -CH 2 -C 6 H 5 , -CH 2 -C 5 H 4 N or -CH 2 -COOH and B represents -CH 2 -COOH. The water-insoluble polymeric iron chelating agent of the present invention offers the advantages of being capable of selectively chelating iron ions, particularly biologically unstable iron, and being insoluble in water, and moreover not being incorporated in metabolic processes in vivo.