| 摘要 |
The present invention relates to a polypeptide binding to human serum albumin and comprising or consisting of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X 1 )(X 2 )(X 3 )(X 4 )(X 5 )(X 6 )D(X 7 )SFHKGEKFQIL(X 8 )(X 9 )(X 10 )(X 11 )(X 12 )G(X 13 )(X 14 )W(X 15 )(X 1 6 )RSLTTG(X 17 )(X 18 )G(X 19 )IPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X 1 ) is A, V, I, L, M, G, P, S, T, N, Q, C, R, H, K, D or E; (X 2 ) is R, H, K, A, V, I, L, M, G, P, S, T, N, Q or C; (X 3 ) is R, H, K, S, T, N, Q, C, F, Y, W, A, V, I, L, M, G or P; (X 4 ) is S, T, N, Q, C, A, V, I, L, M, G, P, R, H, K, F, Y, W, D or E; (X 5 ) is S, T, N, Q, C, D, E, F, Y, W, A, V, I, L, M, G, P, R, H or K; (X 6 ) is F, Y, W, A, V, I, L, M, G, P, R, H, K, S, T, N, Q or C; (X 7 ) is A, V, I, L, M, G, P, R, H or K; (X 8 ) is S, T, N, Q, C, D or E; (X 9 ) is S, T, N, Q, C, D, E, A, V, I, L, M, G, P, F, Y or W; (X 10 ) is A, V, I, L, M, G or P; (X 11 ) is F, Y, W, R, H or K; (X 12 ) is S, T, N, Q, C, F, Y or W; (X 13 ) is F, Y, W, R, H, K, S, T, N, Q, C, D, E, A, V, I, L, M, G or P; (X 14 ) is F, Y, W, A, V, I, L, M, G or P; (X 15 ) is D, E, A, V, I, L, M, G or P; (X 16 ) is A, V, I, L, M, G or P; (X 17 ) is D, E, A, V, I, L, M, G, P, R, H or K; (X 18 ) is S, T, N, Q, C, A, V, I, L, M, G or P; (X 19 ) is F, Y, W, S, T, N, Q or C; and (b) an amino acid sequence which is at least 90% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X 1 ) to (X 19 ). |
