| 摘要 |
A method for preparing an antimicrobial preparation comprising crystalline particles of an antimicrobial peptide/polyene, said method comprising: (i) providing an aqueous liquid composition comprising said antimicrobial and at least one non-ionic surfactant in solution, wherein the non-ionic surfactant is present at a concentration above its critical micelle concentration (CMC) in said composition, and (ii) diluting said composition with an amount of aqueous solvent sufficient to lower the concentration of the said at least one non-ionic surfactant to a concentration at or below its CMC, thereby resulting in the formation of crystalline particles of said antimicrobial and thereby obtaining a liquid preparation comprising the same, and optionally (iii) isolating at least a portion of said crystalline particles from said liquid preparation and/or removing at least a portion of the liquid phase of the liquid preparation to provide a more concentrated liquid preparation of crystalline particles. |
