发明名称 |
METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLO [3.1.0]HEXANE DERIVATIVE USING ENZYME |
摘要 |
There is provided a process for producing a bicyclo [3.1.0] hexane derivative represented by the formula (I) and a salt thereof including; causing an enzyme to act on an optically inactive compound represented by the formula (II) causing an asymmetric acylation reaction and a highly-stereoselective conversion to an optically active compound represented by the formula (III); and converting the compound represented by the formula (III) to the compound represented by the formula (I) or a salt thereof. |
申请公布号 |
EP2502897(B1) |
申请公布日期 |
2014.07.09 |
申请号 |
EP20100831333 |
申请日期 |
2010.11.18 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD. |
发明人 |
SASAKI, JOJI |
分类号 |
C07C67/303;C07B53/00;C07B57/00;C07B61/00;C07C69/753;C12P7/62 |
主分类号 |
C07C67/303 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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