发明名称
摘要 <p>The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steriod, on the regulation of expression of the CYP3A4 gene in a human.</p>
申请公布号 JP5543771(B2) 申请公布日期 2014.07.09
申请号 JP20090297935 申请日期 2009.12.28
申请人 发明人
分类号 A01K67/027;A61K49/00;C12N5/10;C12N9/02;C12N15/09;C12N15/63;C12N15/85;C12Q1/68;G01N33/15;G01N33/50 主分类号 A01K67/027
代理机构 代理人
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