发明名称 |
CRYSTALLINE DIACYLHYDRAZINE AND THE USE THEREOF |
摘要 |
The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject. |
申请公布号 |
EP2751072(A1) |
申请公布日期 |
2014.07.09 |
申请号 |
EP20120829775 |
申请日期 |
2012.09.07 |
申请人 |
INTREXON CORPORATION |
发明人 |
HORMANN, ROBERT, E.;SHULMAN, INNA;RODEL, EVA;HILFIKER, ROLF;DEPAUL, SUSAN, M. |
分类号 |
C07C243/18;C12N5/10 |
主分类号 |
C07C243/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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