发明名称 |
VACCINE PREPARATION FOR CANCER TREATMENT |
摘要 |
[Problem] To provide a method of clearly deriving killer T cells and helper T cells in a cancer treatment vaccine in which the vaccine antibody is a synthetic long peptide which is derived from a tumor-specific antigen protein and/or pathogen-derived protein and which simultaneously contains a CD8-positive, cytotoxic T-cell recognizing epitope and a CD4-poritive, helper T-cell recognizing epitope peptide. [Solution] BY simultaneously dosing an immunopotentiating agent with a conjugate of a hydrophobized polysaccharide (the antigen delivery system) to the synthetic long peptide, it is possible to achieve clear derivation of antigen-specific killer T-cells and helper T-cells from the cancer treatment vaccine in which the synthetic long peptide is the antigen. |
申请公布号 |
EP2752198(A1) |
申请公布日期 |
2014.07.09 |
申请号 |
EP20120827124 |
申请日期 |
2012.08.30 |
申请人 |
MIE UNIVERSITY;NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY |
发明人 |
SHIKU, HIROSHI;HARADA, NAOZUMI;MURAOKA, DAISUKE;AKIYOSHI, KAZUNARI |
分类号 |
A61K39/00;A61K39/12;A61K45/00;A61K47/36;A61K47/48;A61P31/12;A61P35/00;C07K14/00;C07K19/00;C12N15/117 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|