发明名称 |
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE |
摘要 |
<p>The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein. Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates.</p> |
申请公布号 |
EP2751088(A1) |
申请公布日期 |
2014.07.09 |
申请号 |
EP20120772853 |
申请日期 |
2012.09.28 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER, JEAN-DAMIEN;YOUNG, STEPHEN, CLINTON;DAVIS, CHRISTOPHER, JOHN;STUDLEY, JOHN |
分类号 |
C07D265/30;A61K31/497;A61P35/00;C07D401/04;C07D413/04;C07D413/14 |
主分类号 |
C07D265/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|