发明名称 |
V. CHOLERAE HYPEREXPRESSING RECOMBINANT CHOLERA TOXIN B SUBUNIT SHOWING DUAL IMMUNOGENICITY |
摘要 |
<p>Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the delivery of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.</p> |
申请公布号 |
CA2684742(C) |
申请公布日期 |
2014.07.08 |
申请号 |
CA20082684742 |
申请日期 |
2008.04.24 |
申请人 |
CELLDEX THERAPEUTICS, INC. |
发明人 |
KILLEEN, KEVIN P.;ROLAND, KENNETH L.;THOMAS, LAWRENCE J. |
分类号 |
A61K39/116;A61K39/106;A61K39/108;A61P31/04;A61P37/04;C07K14/28;C12N1/21 |
主分类号 |
A61K39/116 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|