NOVEL HUMAN DLL4 MONOCLONAL ANTIBODY THAT POTENTLY INHIBITS THE NOTCH SIGNALING PATHWAY

摘要

The present invention a novel human monoclonal antibody which specifically binds to a delta-like-ligand 4 (DLL4) and, more specifically, to a human monoclonal antibody which effectively inhibits the binding between a DLL4 and a notch receptor by specifically binding to a human DLL4, a polynucleotide for coding the human monoclonal antibody, an expression vector including the polynucleotide, a transformant including the expression vector, a method for manufacturing the human monoclonal antibody, a cancer-preventive or curing pharmacological composition including the human monoclonal antibody, a method for curing a cancer using the human monoclonal antibody, a diagnostic composition including the human monoclonal antibody, a method for providing information for diagnosing a cancer using the human monoclonal antibody, and an autoimmune-preventive or curing pharmacological composition including the human monoclonal antibody, and a method for curing the autoimmune using the human monoclonal antibody.