TRPV3 modulators

摘要

Disclosed herein are modulators of TRPV3 of Formula (I);
wherein p is 1, 2, 3, or 4, and G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

主权项

1. A compound according to Formula (I):or a salt thereof, wherein:
Ra and Rb are each absent; u is 0; X3 is CH2; X4 is (CH2)m; X5 is (CH2)n; m and n are each 1; each Z1 group is a substituent on the X3 carbon atom of the ring containing X3, X4, and X5 and is independently halogen oxo C1-C4-alkyl, or —ORc; or two Z1 groups that are situated on the X3 carbon atom, together with the carbon atom to which they are attached, form a 5-membered monocyclic heterocycle ring comprising two oxygen ring atoms; Rc is hydrogen C1-C4-alkyl; p is 1 or 2; X1 is —OH and X2 is hydrogen; G1 is pyridinyl or pyrimidinyl; each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen C1-C6-alkyl, C1-C6-haloalkyl, and N(Rgc)2; Rgc is hydrogen or C1-C6-alkyl; G2 is G2d; G2d is phenyl, pyridinyl, or pyrimidinyl; each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, —CN, C1-C6-alkyl, C1-C6-haloalkyl, and —ORf; and Rf is C1-C6-alkyl or C1-C6-haloalkyl.