摘要 |
The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof; and to the pharmaceutical composition as well as the preparation method of the said compounds. The said compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like. (see formula I) |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;TOPHARMAN SHANGHAI CO., LTD.;TOPHARMAN SHANDONG CO., LTD. |
发明人 |
LIU, ZHENG;LI, JIANFENG;YANG, XIAOJUN;WANG, ZHEN;ZHANG, JINFENG;ZHU, YI;TIAN, GUANGHUI;JIN, QING;SHEN, JINGKANG;ZHU, WEILIANG;JIANG, HUALIANG;SHEN, JINGSHAN |