| 主权项 |
1. A substituted spiro compound corresponding to formula I wherein m is 0, 1, 2, 3 or 4, n is 1, R1 represents a —C(═O)—R9 group; R2 represents
a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally having at least one heteroatom as chain member;an unsubstituted or mono- or polysubstituted, unsaturated or saturated cycloaliphatic group which optionally has at least one heteroatom as ring member and can be bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally having at least one heteroatom as chain member and/or condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system,a phenyl group, unsubstituted or mono- or polysubstituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, —CN, —CF3, —SF5, —OH, —O—C1-10 alkyl, —NH2, —NO2, —O—CF3, —S—CF3, —SH, —S—C1-5 alkyl, —C1-10 alkyl, —C(═O)—OH, —C(═O)—O—C1-5 alkyl, —O—C(═O)—C1-5 alkyl, —NH—C1-5 alkyl, —N(C1-5 alkyl)2, —NH—C(═O)—O—C1-5 alkyl, —C(═O)—H, —C(═O)—C1-5 alkyl, —C(═O)—NH2, —C(═O)—NH—C1-5 alkyl, C(═O)—N—(C1-5 alkyl)2, —S(═O)2—C1-5 alkyl, —S(═O)2 phenyl, —NH—S(═O)2—C1-5 alkyl, —NH—S(═O)2—C1-5 alkylenephenyl, —NH—S(═O)2—C1-5 alkylenenaphthyl, —NH—S(═O)2 phenyl, —NH—S(═O)2 naphthyl, —S(═O)2—NH—C1-5 alkyl, cyclohexyl, cyclopentyl, morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, pyridinyl, pyridazinyl, —(CH2)-benzo[b]furanyl, —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic portion of the radicals pyridinyl, cyclopentyl, cyclohexyl, morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, pyridazinyl, —S(═O)2 phenyl, —O-phenyl, —O-benzyl, phenyl, —(CH2)-benzo[b]furanyl, —NH—S(═O)2—C1-5 alkylenephenyl, —NH—S(═O)2—C1-5 alkylenenaphthyl, —NH—S(═O)2 phenyl, —NH—S(═O)2 naphthyl and benzyl can be substituted with 1, 2, 3, 4 or 5 substituents selected independently of one another from the group consisting of F, Cl, Br, —OH, —CF3, —SF5, —CN, —NO2, —C1-5 alkyl, —O—C1-5 alkyl, —O—CF3, —S—CF3, phenyl and —O-benzyl, with the proviso that either of the two meta positions and the para position of said phenyl group are not both substituted with substituents which are respectively bound to the phenyl group via an identical atom selected from the group consisting of oxygen, sulfur and nitrogen;an unsubstituted or mono- or polysubstituted group selected from the group consisting of naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyranyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl, benzotriazolyl, benzisoxazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl; 2H-benzo[1.4]oxazin-3(4H)-onyl, (3,4)-dihydroquinolin-2(1H)-onyl, [3,4]-dihydro-2H-1,4-benzoxazinyl and benzothiazolyl, oran unsubstituted or mono- or polysubstituted aryl or heteroaryl group which is bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally having at least one heteroatom as chain member and optionally can be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system; R3 represents a halogen group, a nitro group, a hydroxy group, a thiol group; an —O—R11 group, an —S—R12 group, or a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group; R4 represents hydrogen; R9 represents
a linear or branched, saturated or unsaturated, aliphatic group, unsubstituted or mono- or polysubstituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, —CN, —NO2, —OH, —SH and —NH2, wherein said aliphatic group is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neo-pentyl, n-hexyl, 2-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl, n-hexadecyl, n-heptadecyl, n-octadecyl, n-nonadecyl, n-eicosanyl, —(CH2)—(CH2)—(C(CH3)3), —(CH2)—(CH)(C2H5)—(CH2)—(CH2)—(CH2)—(CH3), ethenyl (vinyl), ethinyl, propenyl (—CH2CH═CH2, —CH═CH—CH3, —C(═CH2)—CH3), 2-methylpropenyl, propinyl (—CH2—C≡CH, —C≡C—CH3), butenyl, butinyl, pentenyl, pentinyl, hexenyl, hexinyl, octenyl and octinyl;oran unsubstituted or mono- or polysubstituted aryl or heteroaryl group which can be bound via a linear or branched, alkylene, alkenylene, or alkinylene group, unsubstituted or mono- or polysubstituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —OH, —SH, —NH2, —CN, —NO2 and phenyl, wherein the phenyl radical can be substituted with 1, 2, 3, 4 or 5 substituents selected independently of one another from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl and neo-pentyl, and/or condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system, wherein said alkylene group is selected from the group consisting of —(CH2)—, —(CH2)2—, —C(H)(CH3)—, —C(CH3)2—, —(CH2)3—, —(CH2)4—, —(CH2)5—, —C(H)(CH3)—(CH2)—, and —C(H)(C2H5)—(CH2)—; and R11 and R12 each independently represent
a linear or branched, saturated or unsaturated, unsubstituted aliphatic group;an unsubstituted, unsaturated or saturated cycloaliphatic group which optionally has at least one heteroatom as ring member and can be bound via a linear or branched, unsubstituted alkylene, alkenylene or alkinylene group and/or condensed with an unsubstituted mono- or polycyclic ring system, oran unsubstituted aryl or heteroaryl group which can be bound via a linear or branched, unsubstituted alkylene, alkenylene or alkinylene group and/or condensed with an unsubstituted mono- or polycyclic ring system;wherein the substituents of the above-mentioned aliphatic groups can be independently selected from the group consisting of F, Cl, Br, I, —CN, —NO2, —OH, —SH and —NH2;or a salt thereof. |
