Method of using salmon thrombin to alleviate pain

摘要

A method of alleviating pain associated with tissue damage includes applying salmon thrombin at a tissue damage site, as a single substance in liquid form, or as a powder, a foam, and/or a gel that includes salmon thrombin. A pain relief substance includes a salmon thrombin preparation.

主权项

1. A method of alleviating nociceptive pain associated with tissue damage, consisting essentially of administering salmon thrombin at a tissue damage site to slow the rate of protease activated receptor 1 (PAR1) activation at the tissue damage site, as demonstrated by the relative rate at which salmon and human thrombin cleave tetrapeptides based on the activation sites of PAR1, thereby diminishing a degree of pain experienced at the site.