Compositions for chemical and biological defense

摘要

One aspect of the present invention relates to reactive compositions and methods of use thereof, wherein a metal oxide cluster is used to connect a reactive group (or groups) to the surface of a substrate. In certain embodiments, the reactive group in the compositions decomposes organophosphate agents through nucleophilic hydrolysis. In certain embodiments, the reactive group in the compositions is bactericidal. Remarkably, the use of metal oxide clusters in the disclosed compositions and methods permits incorporation of higher quantities of nucleophilic and bactericidal groups without the difficulties associated with having to pretreat the substrate prior to its association with the reactive groups.

主权项

1. A composition, comprising a substrate, a cluster, and a reactive group, wherein
the cluster comprises ceria, silica, titania, or an iron oxide; the reactive group comprises an oximate, an iodosobenzoate, an iodoxybenzoate, an amidooxime, a hydroxamate, an imidazole, an amine, a peroxide, a guanidine, a nucleophile, an oxidant, or a bactericide; a bond connects the cluster to the substrate; and a linker connects the cluster to the reactive group or a second bond connects the cluster to the reactive group.