Compositions comprising apolipoprotein A polypeptide and interleukin 15, and methods of treatment using the same

摘要

The present invention relates to compositions capable of promoting both the innate immune response as well as the adaptive immune response in a subject based on the jointly use of ApoA, interleukin 15 and the Sushi domain of the IL15 receptor alpha chain, as well as to the use of these compositions for the stimulation of the immune response in a patient and to therapeutic methods for the treatment of infectious and neoplastic diseases.

主权项

1. A composition comprising, separately or in the form of a single fusion molecule,
(i) a first component selected from the group of
(a) a polypeptide comprising an Apolipoprotein A “Apo A” polypeptide and(b) a polynucleotide encoding an Apo A polypeptide and (ii) a second component selected from the group of
(a) Interleukin 15 “IL15” and(b) a polynucleotide encoding IL15 and (iii) a third component selected from the group of
(a) the Sushi domain of the IL15 receptor alpha chain and(b) a polynucleotide encoding the Sushi domain of the IL15 receptor alpha chain.