Stealth polymeric particles for delivery of bioactive or diagnostic agents

摘要

The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

主权项

1. A blend of polymeric particles comprising a polymer which comprises a copolymer of poly(alklyene glycol-graft-acrylate), which copolymer is a free radical dispersion polymerization product of polyalkylene glycol and an acrylate, the copolymer optionally crosslinked by at least one hydrolysable crosslinker, the copolymer polymerized at 0° C. to about 25° C.