Bromo-phenyl substituted thiazolyl dihydropyrimidines

摘要

This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.

主权项

1. A compound having formula (I) or its isomer (Ia): or an enantiomer or a salt thereof, wherein R1 is o-bromine, R2 is p-fluorine, R3 is a C1-C4 alkyl, R6 is thiazolyl-2-yl, X is methylene, and Z is morpholinyl.