发明名称 |
CHROMOSOME 3P21.3 GENES ARE TUMOR SUPPRESSORS |
摘要 |
Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A Group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3. |
申请公布号 |
CA2415422(C) |
申请公布日期 |
2014.07.08 |
申请号 |
CA20012415422 |
申请日期 |
2001.07.10 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
JI, LIN;MINNA, JOHN;ROTH, JACK;LERMAN, MICHAEL |
分类号 |
C12N15/12;A01K67/00;A01K67/027;A61K31/7088;A61K35/76;A61K38/00;A61K48/00;A61P35/00;A61P35/04;C07K14/47;C07K14/82;C07K16/18;C07K16/32;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/12;C12N15/09;C12N15/85;C12N15/861;C12P21/00;C12Q1/68;G01N33/53;G01N33/566;G01N33/574 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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