发明名称 |
Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
摘要 |
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease.; |
申请公布号 |
US8772342(B2) |
申请公布日期 |
2014.07.08 |
申请号 |
US201013511170 |
申请日期 |
2010.11.26 |
申请人 |
GENFIT |
发明人 |
Darteil Raphael;Hanf Rémy;Hum Dean;Dufour Ingrid |
分类号 |
A61K31/192 |
主分类号 |
A61K31/192 |
代理机构 |
Nixon & Vanderhye P.C. |
代理人 |
Nixon & Vanderhye P.C. |
主权项 |
1. A method for the treatment of a non-alcoholic fatty liver disease in a subject in need thereof, comprising administering to the subject a compound selected from 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one or a pharmaceutically acceptable salt or a stereoisomer thereof. |
地址 |
Loos FR |