Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process

摘要

Described herein are piperidine and piperazine compounds useful for treating neurodegenerated diseases characterized by a lack of dopamine neuron activity. The compounds are also useful for imaging dopamine neurons.

主权项

1. A compound of Formula IV wherein: m is an integer of 1 to 6; B is —O—, —N(H)—, —C(═O)N(H)—, or —N(H)C(═O)—; X and Y can be the same or different and are selected from the group consisting of hydrogen, halo, haloalkyl, alkyl, aryl, (C1-C6)alkoxy, —SH, and —SR; R is optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, or optionally substituted 1,2,4-oxadiazol-5-yl; and V is hydrogen, —C(═O)N(H)-aryl, —C(═O)-alkyl, —SO2-aryl, alkyl, alkenyl, alkynyl, haloaryl, or alkyl halophenyl, wherein aryl or alkyl is optionally substituted.