Biocompatible materials for medical devices

摘要

The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.

主权项

1. A method of producing nitric oxide comprising: providing a composition comprising a three-dimensional metal-organic framework; exposing the composition to physiological fluid including a nitric-oxide-releasing compound; and continuously producing nitric oxide from the nitric oxide releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework, wherein the metal-organic framework comprises Cu3(1,3,5-benzenetricarboxylic acid)2.