Systems and methods for in vivo measurement of interstitial biological activity, processes and/or compositions

摘要

Provided are systems and methods for detecting and/or measuring in vivo interstitial biological activity, processes, and or compounds in human or animal subjects.

主权项

1. A method of real-time in vivo monitoring of a biological process, comprising:
identifying a compound of interest that is located in the non-cardiac interstitium of the subject, wherein the activity or presence of the compound is related to the in vivo biological process being monitored; positioning a probe within the non-cardiac interstitium of the subject; infusing the interstitium of the subject with a fluorogenic substrate specific for the compound of interest wherein the substrate is infused therethrough the probe; receiving interstitial fluid from the subject with the probe, wherein the interstitial fluid comprises the substrate; and detecting the received substrate to monitor the biological process in the subject.