发明名称 |
GROWTH DIFFERENTIATION FACTOR RECEPTORS, AGONISTS AND ANTAGONISTS THEREOF, AND METHODS OF USING SAME |
摘要 |
The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development of metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject. The invention also provides a method of modulating the growth of muscle tissue or adipose tissue in a eukaryotic organism by administering an agent that affects myostatin signal transduction to the organism. |
申请公布号 |
CA2417568(C) |
申请公布日期 |
2014.07.08 |
申请号 |
CA20012417568 |
申请日期 |
2001.07.26 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
LEE, SE-JIN;MCPHERRON, ALEXANDRA C. |
分类号 |
C12N15/18;G01N33/50;A01K67/027;A61K31/7088;A61K38/22;A61K39/395;A61K45/00;A61K48/00;A61P1/14;A61P3/00;A61P3/04;A61P3/10;A61P21/00;A61P25/02;A61P43/00;C07K14/47;C07K14/475;C07K14/71;C07K14/715;C07K16/28;C07K16/42;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/63;C12N15/85;G01N33/15;G01N33/53;G01N33/566;G01N33/74 |
主分类号 |
C12N15/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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