Methods and apparatus for rapid endovascular vessel occlusion and blood flow interruption

摘要

An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.

主权项

1. A medical device for use in occluding a lumen of a body cavity, comprising:
an expandable member having a lumen passing therethrough; the expandable member being expandable from a first conformation to a second conformation; wherein the device is configured to engage a surface of the body cavity when the expandable member is in the second conformation; and a flow-limiting member with first and second end portions opposite one another, the flow-limiting member being coupled to the expandable member; wherein the flow-limiting member comprises a valve positioned at a first end section of the expandable member; wherein the valve is movable between an open and a closed configuration; wherein the valve comprises a first leaflet and a second leaflet that are movable between the open configuration and the closed configuration, and when the first leaflet and the second leaflet are in the closed configuration, the first leaflet is in contact with the second leaflet; wherein the flow-limiting member is configured such that when a force directed proximally is exerted on the first end portion, the first end portion inverts from a non-inverted configuration to an inverted configuration such that the first end portion moves toward the second end portion and such that a bias force increases a contact pressure between the first leaflet and the second leaflet; wherein, when in the closed configuration and placed in the lumen of the body cavity, the valve substantially prevents a flow of a fluid in the lumen of the body cavity past the flow-limiting member; wherein, after the first portion inverts from the non-inverted configuration to the inverted configuration, the first and second leaflets each remain substantially at a same angle, relative to a direction of the inverting, as before the inverting; and wherein the first leaflet extends, from a non-free end of the first leaflet to a free end of the first leaflet, in substantially the same direction before and after the inverting.