发明名称 |
URACYLSPIROOXETANNUKLEOSIDER |
摘要 |
Compounds of the formula I:
including any possible stereoisomers thereof, wherein:
R 4
is a monophosphate, diphosphate or triphosphate ester; or R 4 is
R 7
is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl;
R 8 and R 8'
are hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; or R 8 and R 8' form C 3 -C 7 cycloalkyl;
R 9
is C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, phenyl or phenyl-C 1 -C 6 alkyl, wherein the phenyl moiety in phenyl or phenyl-C 1 -C 6 alkyl is optionally substituted;
or a pharmaceutically acceptable salt or solvate thereof;
pharmaceutical formulations and the use of compounds I as HCV inhibitors. |
申请公布号 |
DK2511282(T3) |
申请公布日期 |
2014.07.07 |
申请号 |
DK20120176402T |
申请日期 |
2010.05.11 |
申请人 |
JANSSEN PRODUCTS, L.P.;MEDIVIR AB |
发明人 |
JONCKERS, TIM HUGO MARIA;RABOISSON, PIERRE JEAN-MARIE BERNARD;VANDYCK, KOEN;VAN HOOF, STEVEN MAURICE PAULA;HU, LILI;TAHRI, ABDELLAH |
分类号 |
C07H19/06;A61K31/7072;C07D201/00;C07D493/10;C07H15/04;C07H15/18;C07H19/067;C07H19/10 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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