A PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING INTERFERON ALPHA CONJUGATE

摘要

The present invention relates to an anti-cancer pharmaceutical composition comprising an interferon alpha or a polymer conjugate thereof and a use for the treatment of cancer by co-administration of the composition in conjunction with anti-cancer agents. The interferon alpha conjugate of the present invention shows a longer in-vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha and, in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition of the present invention has an excellent in-vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having the excellent anti-cancer activity reduces administration dose of the anti-cancer agent, thereby reducing side effects of the anti-cancer agent and increasing the compliance of a patient to the treatment.