| 发明名称 |
CATALYTIC DELIVERY NANOSUBSTRATES (CDNS) FOR HIGHLY EFFICIENT DELIVERY OF BIOMOLECULES |
| 摘要 |
This invention relates, e.g., to a molecular delivery system comprising A. a substrate having a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the substrate, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises, encapsulated therein, a molecule of interest, and on its surface, multiple copies of second member of the binding pair. Methods of using the molecular delivery system to deliver a molecule of interest to a cell are also described. |
| 申请公布号 |
US2014186426(A1) |
申请公布日期 |
2014.07.03 |
| 申请号 |
US201214234321 |
申请日期 |
2012.07.23 |
| 申请人 |
Tseng Hsian-Rong;Wang Hao;Chen Kuan-Ju |
发明人 |
Tseng Hsian-Rong;Wang Hao;Chen Kuan-Ju |
| 分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A molecular delivery system comprising
A. a substrate having
(i) a nanostructured surface region which comprises a plurality of nanostructures and,(ii) covalently attached to the nanostructured surface region, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises
(i) encapsulated therein, a molecule of interest, and,(ii) on its surface, multiple copies of a second member of the binding pair. |
| 地址 |
Los Angeles CA US |
