DRY GRANULATION PROCESS FOR PRODUCING TABLET COMPOSITIONS OF METFORMIN AND COMPOSITIONS THEREOF
摘要
The present invention pertains to a novel dry granulation method for producing tablet compositions of Metformin as well as a combination thereof with DPP-4 inhibitors. The method involves use of a mixture of MCC&DCPA in specific amounts to bring solution to the problems of conventional processes such as poor compaction, friability and stability.
申请公布号
WO2014101986(A1)
申请公布日期
2014.07.03
申请号
WO2013EP03805
申请日期
2013.12.17
申请人
ZENTIVA SA&Gbreve,LIK ÜRÜNLERI SAN. VE TIC. A.&Scedil,.
发明人
A&Scedil,HAR, GÖZDE;ORAN, UMUT;N&Idot,T&Idot,K, NACI;ADIYAMAN, MUSTAFA