| 发明名称 |
INHIBITORS OF VIRAL INTEGRASE AND METHODS OF USE |
| 摘要 |
Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing HIV. Also disclosed are methods of identifying agents that inhibit HIV viral mutants that are resistant to integrase inhibitors. |
| 申请公布号 |
US2014187477(A1) |
申请公布日期 |
2014.07.03 |
| 申请号 |
US201414197016 |
申请日期 |
2014.03.04 |
| 申请人 |
The United Sates of America, as Represented by the Secretary, Department of Health and Human Service ;Integratech Proteomics, LLC |
发明人 |
Sandrock Tanya;Craigie Robert |
| 分类号 |
C07K7/08 |
主分类号 |
C07K7/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An HIV integrase inhibiting peptide analog comprising an amino acid sequence having at least 90% sequence homology to SEQ ID NO:1, or a variant thereof, wherein the variant consists of a deletion of the N-terminal residue or C-terminal residue, wherein the peptide comprises amino acids or amino acid analogs that are connected by non-peptide linkages. |
| 地址 |
Bethesda MD US |
