| 摘要 |
PROBLEM TO BE SOLVED: To provide a BMP mutant having low sensitivity to noggin.SOLUTION: The present invention provides modified, highly potent bone morphogenetic proteins. In particular, the present invention relates to an observation that BMP-6 and BMP-9 are less susceptible to inhibition by Noggin than the other members of the BMP subfamily of proteins. The present invention features a chimeric bone morphogenetic protein having a middle portion of BMP-6 or BMP-9 replacing the corresponding portion of a BMP subfamily protein other than BMP-6 and BMP-9 to cause resistance to inhibition by Noggin or other Noggin-like antagonists. Other embodiments of modified BMPs, compositions and methods of use are also included. |
