METHOD OF USING PI3K AND MEK MODULATORS

摘要

PROBLEM TO BE SOLVED: To provide methods of treating cancer with a combination of compounds which modulate protein kinase enzymatic activities.SOLUTION: The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K. This invention also provides a method of using an MEK inhibitor of Formula I, Ia, Ic, Id, II, III, IV, or V in combination with a PI3K inhibitor of Formula VI, VIa, VIb, or VII, or in combination with a PI3K inhibitor of Formula VIII, VIIIa, VIIIb, IX, X, XI or XI for the treatment of hyperproliferative disorders, such as cancers.